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Identification and Application of Biomarkers in Molecular and Genomic Epidemiologic Research / 예방의학회지
Article in En | WPRIM | ID: wpr-181035
Responsible library: WPRO
ABSTRACT
Biomarkers are characteristic biological properties that can be detected and measured in a variety of biological matrices in the human body, including the blood and tissue, to give an indication of whether there is a threat of disease, if a disease already exists, or how such a disease may develop in an individual case. Along the continuum from exposure to clinical disease and progression, exposure, internal dose, biologically effective dose, early biological effect, altered structure and/or function, clinical disease, and disease progression can potentially be observed and quantified using biomarkers. While the traditional discovery of biomarkers has been a slow process, the advent of molecular and genomic medicine has resulted in explosive growth in the discovery of new biomarkers. In this review, issues in evaluating biomarkers will be discussed and the biomarkers of environmental exposure, early biologic effect, and susceptibility identified and validated in epidemiological studies will be summarized. The spectrum of genomic approaches currently used to identify and apply biomarkers and strategies to validate genomic biomarkers will also be discussed.
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Full text: 1 Index: WPRIM Main subject: Genetic Markers / Epidemiologic Studies / Molecular Epidemiology / Disease Progression / Environmental Exposure / Republic of Korea / Neoplasms Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Humans Country/Region as subject: Asia Language: En Journal: Journal of Preventive Medicine and Public Health Year: 2009 Type: Article
Full text: 1 Index: WPRIM Main subject: Genetic Markers / Epidemiologic Studies / Molecular Epidemiology / Disease Progression / Environmental Exposure / Republic of Korea / Neoplasms Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Limits: Humans Country/Region as subject: Asia Language: En Journal: Journal of Preventive Medicine and Public Health Year: 2009 Type: Article