Maintenance of CD8+T-cell anergy by CD4+CD25+ regulatory T cells in chronic graft-versus-host disease
Experimental & Molecular Medicine
; : 494-501, 2006.
Article
in En
| WPRIM
| ID: wpr-181050
Responsible library:
WPRO
ABSTRACT
In a murine model of systemic lupus erythematosus (SLE)-like chronic graft-versus-host disease (cGVHD), donor CD8+T cells rapidly fall into anergy to host cells, while donor CD4+T cells hyperactivate B cells and break B-cell tolerance to self-Ags in the recipient mouse. The functional recovery of donor CD8+T cells can result in the conversion of cGVHD to acute GVHD (aGVHD), indicating that donor CD8+T-cell anergy is a restriction factor in the development of cGVHD. In this report, we present evidence that donor CD4+CD25+regulatory T cells (T(reg) cells) are critical in maintaining the donor CD8+T-cell anergy and thus suppressing the development of aGVHD in mice that are naturally prone to cGVHD. Our results provide a novel insight into the role of T(reg) cells in determining cGVHD versus aGVHD.
Key words
Full text:
1
Index:
WPRIM
Main subject:
CD4-Positive T-Lymphocytes
/
Chronic Disease
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T-Lymphocytes, Regulatory
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Clonal Anergy
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CD8-Positive T-Lymphocytes
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Interleukin-2 Receptor alpha Subunit
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Graft vs Host Disease
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Immune Tolerance
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Mice, Inbred DBA
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Experimental & Molecular Medicine
Year:
2006
Type:
Article