Transfusion-related Cytomegalovirus Infection Among Very Low Birth Weight Infants in an Endemic Area
Journal of Korean Medical Science
;
: 5-10, 2006.
Article
in English
| WPRIM
| ID: wpr-181127
ABSTRACT
This study investigated the incidence of acquired cytomegalovirus (CMV) infection in very low birth weight infants (VLBWI) given CMV seropositive blood, and sought to determine whether filtering and irradiation of blood products could help prevent CMV infection and the time required to clear passively-derived anti-CMV IgG among 80 VLBWI transfused with filtered-irradiated blood, 20 VLBWI transfused with nonfiltered- nonirradiated blood and 26 nontransfused VLBWI. CMV IgG and IgM values were obtained from all blood products prior to transfusions, and from VLBWI at birth until the infants became seronegative. Urine was obtained for CMV culture at birth and every 3-4 weeks until 12 weeks after the final transfusion. The incidence of CMV IgG seropositivity among the 126 infants at birth and the blood products given were 96% and 95%, respectively. The incidence of acquired CMV infection was 4/100 (4%) in the transfused group 2/80 (2.5%) and 2/20 (10%) in the filtered-irradiated and nonfiltered-nonirradiated transfusion groups, respectively. Approximately 9-10 months elapsed to clear passively acquired CMV IgG. The irradiation and filtering of the blood products did not seem to decrease the transfusion-related CMV infection rate in Korea among VLBWI, however, further validation is recommended in a larger cohort of infants.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Time Factors
/
Blood Donors
/
Blood Transfusion
/
Immunoglobulin G
/
Immunoglobulin M
/
Comparative Study
/
Intensive Care Units, Neonatal
/
Linear Models
/
Cytomegalovirus Infections
/
Infant, Very Low Birth Weight
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2006
Type:
Article
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