Efficacy and Safety of Calcipotriol/Betamethasone Dipropionate Ointment for the Treatment of Trachyonychia: An Open-Label Study
Annals of Dermatology
;
: 371-375, 2015.
Article
in English
| WPRIM
| ID: wpr-181209
ABSTRACT
BACKGROUND:
Despite efforts to treat trachyonychia, there is no promising treatment modality.OBJECTIVE:
This study evaluated the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment on trachyonychia.METHODS:
A total of 39 patients with 432 nails affected by trachyonychia were enrolled. All patients applied calcipotriol/betamethasone ointment once daily without occlusion for 6 months. Outcome measures were assessed by physician's global assessment (degree of roughness 0, clear; 1, mild; 2, moderate; 3, marked; 4, severe) at all time points.RESULTS:
After 6 months of therapy, 98.6% (426/432) of nails showed significant clinical improvement; 4.2% were completely free from nail lesions. The mean physician global assessment score decreased significantly from 3.5 to 1.7 points (p< 0.05). No serious side effects were reported, except mild pruritus and erythema in 2 patients.CONCLUSION:
This is the first study to prospectively evaluate the efficacy and safety of calcipotriol/betamethasone ointment for the treatment of trachyonychia. The results indicate topical calcipotriol/betamethasone is an effective and safe treatment for symptom improvement of trachyonychia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pruritus
/
Psoriasis
/
Betamethasone
/
Prospective Studies
/
Outcome Assessment, Health Care
/
Erythema
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2015
Type:
Article
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