Effects of Sodium Alginate on the Non-Specfic Defense System of the Common Carp ( Cyprinus carpio L. ) / 대한면역학회지
Korean Journal of Immunology
;
: 71-76, 1999.
Article
in Korean
| WPRIM
| ID: wpr-181224
ABSTRACT
Carp which receive intraperitoneal injections of sodium alginate show a high survival rate after being challenged with Edwardsiella tarda. To elucidate the immunoenhancement by sodium alginate, its effects on the non-specific defense system of carp were investigated. Sodium alginate had little influence either on the activity of the alternative complement pathway or on the phagocytic and respiratory burst activities of head kidney phagocytes (HKP), yet it greatly enhanced the migration of HKP to the peritoneal cavity (the site of injection) and concurrently elevated their phagocytic activity. The number of phagocytes mobilized by sodium alginate was 2 to 50 times greater than that by the well-known peritoneal exudate cell-eliciting agents when injected at the same dose. Accordingly, it is highly probable that the early elimination of challenge bacteria by such mobilized and activated phagocytes was responsible for the high survival rate of the alginateinjected fish. In chemotaxis assays, it was revealed that sodium alginate stimulated sorne leukocyte subpopulation (s) within the peritoneal cavity to produce and/or secrete chemotactic factor (s), while concurrently enhancing the sensitivity of HKP to the factor (s).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peritoneal Cavity
/
Phagocytes
/
Sodium
/
Bacteria
/
Carps
/
Chemotaxis
/
Survival Rate
/
Respiratory Burst
/
Complement Pathway, Alternative
/
Edwardsiella tarda
Language:
Korean
Journal:
Korean Journal of Immunology
Year:
1999
Type:
Article
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