Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse
Experimental & Molecular Medicine
;
: 65-69, 2005.
Article
in English
| WPRIM
| ID: wpr-18129
ABSTRACT
This study was conducted to determine if an oral squamous cell carcinoma alters mRNA expression of serotonin transporter (5-HTT) in the central nervous system. KB cell line derived from a human oral squamous cell carcinoma was inoculated into nude mice, and mRNA expression level of 5-HTT in the dorsal raphe nucleus (DRN) was examined by in situ hybridization when the tumor mass reached to -10% of total body weight. Plasma leptin levels were determined by radioimmunoassay method using a commercial kit. 5-HTT mRNA level was significantly decreased in the DRN of tumor bearing mice, compared to the age-matching non-tumor control. Plasma leptin level decreased concomitantly in tumor bearing mice. These results suggest that oral carcinoma may suppress 5-HTT gene expression in the central nervous system, perhaps in relation with decreased plasma leptin level.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Membrane Transport Proteins
/
Body Weight
/
RNA, Messenger
/
Mouth Neoplasms
/
Radioimmunoassay
/
Raphe Nuclei
/
Membrane Glycoproteins
/
Carcinoma, Squamous Cell
/
Serotonin
/
Gene Expression Regulation, Neoplastic
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2005
Type:
Article
Similar
MEDLINE
...
LILACS
LIS