The Effects of Surfactant Therapy using High Frequency Jet Ventilation on Lung Lavaged Dogs / 대한마취과학회지

ABSTRACT

The effects of exogenous surfactant replacement therapy using high frequency jet ventilation (HFJV) on arterial blood gases changes, pulmonary and hemodynamic variables were observed in lungs lavaged dogs with saline. Lungs were lavaged repeatedly with warm physiological saline until PaO2 fall 100 mmHg level. Surfactant 50 mg/kg was administered in experimental group and saline was administered in control group intratracheally using HFJV. During administration of surfactant using HFJV, all the dogs were not hypoxemic and PaCO2 were within normal range. HFJV was done for 1 hour to make even distribution of the surfactant, After that, controlled mechanical ventilation of the initial condition was eontinued for 3 hours. 1n surfactant administered group, our results showed that significant PaO2 improvement were observed and maintained for 3 hours, bur no significant changes were observed in saline administered group. In this study, we suggest that the effects of exogenous pulmonary surfactant administered using HFJV on acute respiratory failure, induced by repeated lungs lavage with saline, were good and HFJV can be used a safe and effective method for the administration of the pulmonary surfactant.