The Effects of Insulin Treatment on the Contractile Responses of the Seminal Vesicle in Streptozotocin-induced Diabetic Rats / 대한비뇨기과학회지
Korean Journal of Urology
;
: 323-327, 1998.
Article
in Korean
| WPRIM
| ID: wpr-181528
ABSTRACT
PURPOSE:
Diabetes mellitus produces disturbances in reproductive function including decreased serum testosterone levels, however, the effects of diabetes on the contractile function of testosterone-dependent urogenital smooth muscles have not been conclusively established. In this study, the effects of streptozotocin-induced diabetes on the contractile responses of rat seminal vesicle were compared with those of insulin-treated diabetic and control groups. MATERIALS ANDMETHODS:
Diabetes was induced by intraperitoneal injection of streptozotocin(65mg/kg) and in insulin-treated diabetic group, NPH was daily injected by subcutaneous route. All the rats were sacrificed by cervical dislocation after 6 weeks and the seminal vesicles were immediately removed. The changes of contractile response to electrical field stimulation, phenylephrine and KCI administration were measures by polygraphRESULTS:
1. The weights of seminal vesicle in streptozotocin-induced diabetes were significantly decreased than those of insulin-treated diabetic and control groups(p<0.05). 2. Contractile responses of seminal vesicle to electrical field stimulation were significantly decreased in streptozotocin-induced diabetic compared to insulin-treated diabetic and control groups(p<0.05). 3. Streptozotocin-induced diabetes produced significant increase in contractile responses of seminal vesicle to phenylephrine and KCI than insulin-treated diabetic and control groups(p<0.05).CONCLUSIONS:
This study demonstrates that diabetes produce a denervation-like supersensitivity which is specific for receptor-mediated processes and that insulin treatment in diabetic mellitus is able to recover the contractile responses of seminal vesicle.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenylephrine
/
Seminal Vesicles
/
Testosterone
/
Weights and Measures
/
Diabetes Mellitus
/
Joint Dislocations
/
Injections, Intraperitoneal
/
Insulin
/
Muscle, Smooth
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Urology
Year:
1998
Type:
Article
Similar
MEDLINE
...
LILACS
LIS