Clinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: immunohistochemical analysis
The Korean Journal of Internal Medicine
;
: 116-120, 2008.
Article
in English
| WPRIM
| ID: wpr-181618
ABSTRACT
BACKGROUND/AIMS:
The insulin-like growth factor (IGF) system has been implicated in tumor growth, invasion, and metastasis. However, reports on the IGF-1 receptor (IGF-1R) based on radioimmunoassays are conflicting, and its prognostic implications in non-small-cell lung cancer (NSCLC) are still controversial.METHODS:
Seventy-one paraffin-embedded tissue sections from stage I NSCLC patients were stained using a mouse monoclonal antibody against human IGF-1R.RESULTS:
The intensity and frequency of IGF-1R expression on the membrane and cytoplasm of cancer cells was evaluated and scored using a semiquantitative system. IGF-1R expression was detected in nine of 71 (12.7%) cases. No significant relationship was found between clinical/histopathological parameters and IGF-1R expression. None of the patients whose tumor expressed IGF-1R had experienced distant metastasis or cancer-related death, although the difference did not reach statistical significance.CONCLUSIONS:
We conclude that IGF-1R expression may not be a major prognostic factor for stage I NSCLC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Insulin-Like Growth Factor I
/
Immunohistochemistry
/
Receptor, IGF Type 1
/
Carcinoma, Non-Small-Cell Lung
/
Neoplasm Metastasis
/
Neoplasm Staging
Type of study:
Prognostic study
Limits:
Aged80
/
Animals
/
Female
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2008
Type:
Article
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