Effect of Oral Ramosetron for Postoperative Nausea and Vomiting in Surgical Patients using PatientControlled Analgesia / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 63-68, 2008.
Article
in Korean
| WPRIM
| ID: wpr-181764
ABSTRACT
BACKGROUND:
This study was designed to evaluate ramosetron oral disintegrating tablet (ODT), a 5-HT3 receptor antagonist, for prophylaxis and treatment of postoperative nausea and vomiting (PONV) in patients undergoing general anesthesia using patient controlled analgesia (PCA).METHODS:
150 adult, ASA physical status I or II, aged 18-65 yr, patients undergoing elective surgery were enrolled (n = 50 in each). Patients were randomly assigned to one of three groups, group C (no prophylactic antiemetics), groups N (ramosetron ODT 30 minutes before the induction), and group Z (intravenous injection of ondansetron 4 mg at the end of surgery followed by continuous infusion of 8 mg added to the PCA solution). A standard general inhalation anesthesia and IV PCA with fentanyl and ketorolac were used. During the 48 hours after recovery, we assessed pain score by using a visual analogue scale (VAS), a sedation scale, an incidence of PONV, and monitoring consumption of PCA drug, rescue drug consumption, adverse events, and overall satisfaction.RESULTS:
The incidence of nausea and the consumption of rescue drug were significantly decreased in N and Z groups at each time point except 24-48 hours after recovery. There was no significant difference in incidence of vomiting. Overall satisfaction was superior in N and Z groups compared with C group.CONCLUSIONS:
Preoperative administration of ramosetron ODT was an acceptable and effective way to prevent PONV in patients using PCA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vomiting
/
Benzimidazoles
/
Passive Cutaneous Anaphylaxis
/
Fentanyl
/
Incidence
/
Analgesia, Patient-Controlled
/
Ondansetron
/
Postoperative Nausea and Vomiting
/
Ketorolac
/
Receptors, Serotonin, 5-HT3
Type of study:
Incidence study
/
Prognostic study
Limits:
Adult
/
Aged
/
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2008
Type:
Article
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