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NF-kappaB and CREB Are Involved in IL-8 Production of Human Neutrophils Induced by Trichomonas vaginalis-Derived Secretory Products
The Korean Journal of Parasitology ; : 291-294, 2011.
Article in English | WPRIM | ID: wpr-182102
ABSTRACT
Trichomonas vaginalis is a flagellated lumen-dwelling extracellular protozoan parasite that causes human trichomoniasis via sexual intercourse. Human neutrophils play a crucial role in acute tissue inflammatory responses in T. vaginalis infection. In this study, we investigated the signaling mechanism of neutrophil responses when stimulated with T. vaginalis-derived secretory products (TvSP), which were collected from 1x10(7) live trichomonads. Incubation of human neutrophils isolated from peripheral blood with TvSP induced up-regulation of IL-8 protein secretion. In addition, stimulation with TvSP induced phosphorylation of NF-kappaB and CREB in neutrophils. Moreover, TvSP-induced IL-8 production was also significantly inhibited by pretreatment of neutrophils with ikappaB inhibitor or CREB inhibitor. These results suggest that transcription factors NF-kappaB and CREB are involved in IL-8 production in human neutrophils induced by stimulation with T. vaginalis infection.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphorylation / Trichomonas vaginalis / Interleukin-8 / NF-kappa B / Cyclic AMP Response Element-Binding Protein / Human Experimentation / Neutrophils Limits: Humans / Male Language: English Journal: The Korean Journal of Parasitology Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphorylation / Trichomonas vaginalis / Interleukin-8 / NF-kappa B / Cyclic AMP Response Element-Binding Protein / Human Experimentation / Neutrophils Limits: Humans / Male Language: English Journal: The Korean Journal of Parasitology Year: 2011 Type: Article