Developing of Systemic Inflammatory Response Syndrome and Serum TNF-alpha Level in Multiple Trauma Patients
Journal of the Korean Society of Emergency Medicine
;
: 614-621, 1998.
Article
in Korean
| WPRIM
| ID: wpr-182175
ABSTRACT
BACKGROUND AND PURPOSE:
The systemic inflammatory response syndrome(SIRS), as defied recently by critical-care specialists, may result from various etiologies including infection, bum, or trauma. The purpose of this study was to determine whether TNF- alpha is associated with the development of systemic inflammatory response syndrome caused by multiple trauma.METHODS:
The study population consisted of 21 patients with multiple trauma presented emergency department within 2 hours after insult were enrolled in this study Multiple blood samples were serially drawn to measure seam TNF-alpha level on admission, 12 hours, 24 hours, and every day until 5 days after injury. Serum TNF-alpha was measured by ELISA ("Sandwich type"). Blood samples of fifteen volunteers were used as a reference value far serum TNF-alpha.RESULTS:
Serum TNF-alpha. levels of SIRS group were persistency elevated above reference value until 3 days after on admission. Peak seam TNF-alpha level at 12 hours after admission was higher in SIRS group than non-SIRS group(p< 0.05). There was no significant correlation between injury severity score and TNF-alpha levels on regression analysis, all patients with ISS higher than 16 had SIRS. No one had SIRS among patients with ISS less than 16.CONCLUSION:
the result of this study suggests that persistent elevation of TNF-alpha and degree of injury severity are associated with the development of systemic inflammatory response syndrome in multiple trauma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
Specialization
/
Volunteers
/
Enzyme-Linked Immunosorbent Assay
/
Multiple Trauma
/
Injury Severity Score
/
Tumor Necrosis Factor-alpha
/
Systemic Inflammatory Response Syndrome
/
Emergency Service, Hospital
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Society of Emergency Medicine
Year:
1998
Type:
Article
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