Survivin and Bcl-2 expression in eutopic endometrium with and without endometriosis / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 418-427, 2005.
Article
in Korean
| WPRIM
| ID: wpr-182333
ABSTRACT
OBJECTIVE:
To examine expression of survivin and Bcl-2 in eutopic endometrium with endometriosis and without endometriosis by immunohistochemical stain.METHODS:
Expression of survivin and Bcl-2 was immunohistochemically investigated in eutopic endometrium with endometriosis (n=30, study group I; laparoscopy-proved endometriosis, study group II; adenomyosis) or without endometriosis (n=34, control group). The score of immunohistochemical staining was evaluated semi-quantitative method modified by Sinicrope and Lu. Statistical analyses was carried out using one-way ANOVA with Turkey test.RESULTS:
Survivin expression was significantly higher in nucleus of glandular epithelium of eutopic endometrium with endomtriosis compared to that without endometriosis (p<0.05). Increased expression of Bcl-2 was found in glandular epithelium of eutopic endometrium with endometriosis than without endometriosis, but there was no significantly difference.CONCLUSION:
Our findings suggest that increased survivin expression may contribute to survival of endometriosis. Moreover, survivin could play an important role in pathogenesis of endometriosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Turkey
/
Endometriosis
/
Endometrium
/
Epithelium
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2005
Type:
Article
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