Hormone replace therapy and changes in mammographic density in postmenopausal women / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 411-417, 2005.
Article
in Korean
| WPRIM
| ID: wpr-182334
ABSTRACT
OBJECTIVE:
To evaluate the changes in mammographic density by different types of hormone replace therapy (HRT) in postmenopausal women.METHODS:
A total of 150 postmenopausal women who received same HRT regimen for 1 year were classified as the four groups according to the regimen of HRT; 1) daily conjugated equine estrogen (CEE) 0.625 mg+medroxiprogesterone acetate (MPA) 2.5 mg (CEE/MPA-continuous, n=42), 2) daily CEE 0.625 mg+MPA 10 mg on days 1-12 (CEE/MPA-cyclic, n=28), 3) daily CEE 0.625 mg (CEE only, n=40), 4) daily tibolone 2.5 mg (Tibolone, n=40). And 40 women were allocated as control group. The changes in mammographic density in each group were compared with before and after HRT for 1 year.RESULTS:
The increase in mammographic density after 1 year of HRT was significantly higher in CEE/MPA-continuous group and CEE/MPA-cyclic group compaired with control group (p<0.05), and was not observed in CEE only group and tibolone group.CONCLUSION:
Our results suggest that greater increase of mammographic density in postmenopausal women was significantly associated with estrogen/progestin combination therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mammography
/
Estrogens
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2005
Type:
Article
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