Langerhans Cell Histiocytosis That Improved with Oral Isotretinoin Therapy / 대한피부과학회지
Korean Journal of Dermatology
;
: 893-897, 2010.
Article
in Korean
| WPRIM
| ID: wpr-182727
ABSTRACT
Langerhans cell histiocytosis (LCH) is a reactive disease in which abnormal Langerhans cells accumulate in various body sites. We report here on a 51-year-old male patient with LCH that was classified as single-system disease (restricted LCH). The skin lesions were a small, deep ulcer in the right inguinal area and multiple erythematous papules scattered on the lower abdomen, and the patient had these lesions for 1 year. The histopathologic examination revealed a dense histiocytic infiltration in the dermis, and most of the cells showed the characteristics of "LCH" cells. The immunohistochemistry for S-100 protein and CD1a complex all showed positive results. The patient was much improved after surgical excision of the inguinal ulcer and administering oral isotretinoin (20 mg daily) for 8 months, and there was no recurrence. We think retinoid is an effective treatment option for LCH, especially for single system disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Skin
/
Ulcer
/
Immunohistochemistry
/
Isotretinoin
/
S100 Proteins
/
Langerhans Cells
/
Histiocytosis, Langerhans-Cell
/
Dermis
/
Abdomen
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2010
Type:
Article
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