Comparison of Clinical Characteristics between Transient Global Amnesia with and without Acute Focal Lesion in Hippocampus
Journal of the Korean Neurological Association
;
: 312-317, 2016.
Article
in Korean
| WPRIM
| ID: wpr-182776
ABSTRACT
BACKGROUND:
Transient global amnesia (TGA) might be related to an ischemic event with characteristic findings in diffusion-weighted images (DWIs). However, acute lesions are uncommon. The aim of this study was to identify any clinical or radiological differences between TGA patients with and without acute lesions.METHODS:
From January 2010 through March 2015, we identified retrospectively TGA patients with DWIs within 7 days from onset. According to the presence of an acute lesion in the hippocampus, clinical features, vascular risk factors, electroencephalography (EEG) findings, and the regional perfusion status in single-photon-emission computed tomography (SPECT) images were compared.RESULTS:
Of 57 TGA patients (mean age=60.5 years; 40 females), 19 patients (33.3%) had acute focal lesions in the hippocampus (3.53±0.74 mm, mean±SD). In terms of clinical features, the symptom duration was shorter in the lesion-negative group than in the lesion-positive group (mean=5 hours, interquartile range [IQR]=2-9 hours vs. mean=8 hours, IQR=5-13.5 hours; p=0.072). However, there were no differences between TGA patients with and without DWI lesions in cerebrovascular risk factors, laboratory results, or EEG findings. In 6 of 22 patients who underwent cerebral SPECT (2 of 9 DWI lesions and 4 of 13 without lesions), mild perfusion defects were exhibited without significant differences in both medial temporal regions and in the left frontal and left frontotemporal regions.CONCLUSIONS:
Symptom duration was the only clinical difference-including perfusion defects and epileptic evidence-between TGA patients with and without DWI lesions. This suggests that there is a low probability of hypoperfusion or focal seizure in TGA patients without acute lesions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Perfusion
/
Seizures
/
Temporal Lobe
/
Tomography, Emission-Computed, Single-Photon
/
Retrospective Studies
/
Risk Factors
/
Amnesia, Transient Global
/
Electroencephalography
/
Hippocampus
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2016
Type:
Article
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