Expression of 4-1BB and 4-1BBL in Graves'Disease / 대한내분비학회지
Journal of Korean Society of Endocrinology
;
: 116-124, 2006.
Article
in Korean
| WPRIM
| ID: wpr-183002
ABSTRACT
BACKGROUND:
4-1BB mediated costimulatory signal is a recently identified immunotherapeutic strategy for treating autoimmune diseases without depressing the immune response. In this study, we investigated the expression of 4-1BB and 4-1BBL on the peripheral blood mononuclear cells (PBMC) and we assessed whether the serum levels of soluble (s) 4-1BB and s4-1BBL in the patients with Graves' disease (GD) and compared them with normal subjects.METHODS:
Expression of 4-1BB and 4-1BBL on PBMC of GD patients was determined by flow cytometry. The concentrations of s4-1BB and s4-1BBL were assessed in the sera of GD patients by performing ELISA.RESULTS:
4-1BB was constitutively expressed on naive CD4+ and CD8+ T cells of the GD patients and this was increased by stimulation. 4-1BBL was also expressed on the antigen-presenting cells such as CD19+ B cells, monocytes and dendritic cells in GD patients. The serum levels of s4-1BB and s4-1BBL were significantly higher in GD patients than those in controls, and these levels were significantly correlated with the serum levels of thyroid-binding inhibitory immunoglobulin and free T4.CONCLUSION:
These results indicate that effector T cells of GD patients can be activated through the 4-1BB-mediated costimulatory signal. Elevated s4-1BB and s4-1BBL levels in the sera of GD patients may affect modulation of the clinical course in GD patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoimmune Diseases
/
Dendritic Cells
/
Immunoglobulins
/
Enzyme-Linked Immunosorbent Assay
/
B-Lymphocytes
/
Monocytes
/
T-Lymphocytes
/
Graves Disease
/
Flow Cytometry
/
Antigen-Presenting Cells
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Society of Endocrinology
Year:
2006
Type:
Article
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