Effects of MR Parameter Changes on the Quantification of Diffusion Anisotropy and Apparent Diffusion Coefficient in Diffusion Tensor Imaging: Evaluation Using a Diffusional Anisotropic Phantom
Korean Journal of Radiology
;
: 297-303, 2015.
Article
in English
| WPRIM
| ID: wpr-183063
ABSTRACT
OBJECTIVE:
To validate the usefulness of a diffusional anisotropic capillary array phantom and to investigate the effects of diffusion tensor imaging (DTI) parameter changes on diffusion fractional anisotropy (FA) and apparent diffusion coefficient (ADC) using the phantom. MATERIALS ANDMETHODS:
Diffusion tensor imaging of a capillary array phantom was performed with imaging parameter changes, including voxel size, number of sensitivity encoding (SENSE) factor, echo time (TE), number of signal acquisitions, b-value, and number of diffusion gradient directions (NDGD), one-at-a-time in a stepwise-incremental fashion. We repeated the entire series of DTI scans thrice. The coefficients of variation (CoV) were evaluated for FA and ADC, and the correlation between each MR imaging parameter and the corresponding FA and ADC was evaluated using Spearman's correlation analysis.RESULTS:
The capillary array phantom CoVs of FA and ADC were 7.1% and 2.4%, respectively. There were significant correlations between FA and SENSE factor, TE, b-value, and NDGD, as well as significant correlations between ADC and SENSE factor, TE, and b-value.CONCLUSION:
A capillary array phantom enables repeated measurements of FA and ADC. Both FA and ADC can vary when certain parameters are changed during diffusion experiments. We suggest that the capillary array phantom can be used for quality control in longitudinal or multicenter clinical studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Research Design
/
Anisotropy
/
Phantoms, Imaging
/
Diffusion Magnetic Resonance Imaging
/
Diffusion Tensor Imaging
/
Signal-To-Noise Ratio
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
English
Journal:
Korean Journal of Radiology
Year:
2015
Type:
Article
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