Risk Factors for Post-ERCP Pancreatitis in Patients Pretreated with Nafamostat Mesilate / 대한소화기내시경학회지
Korean Journal of Gastrointestinal Endoscopy
;
: 265-270, 2008.
Article
in Korean
| WPRIM
| ID: wpr-183193
ABSTRACT
BACKGOUND/AIMS:
Pancreatitis is the most common and important complication of an endoscopic retrograde cholangiopancreatography (ERCP). The aim of this study was to identify risk factors for post ERCP-pancreatitis in patients pretreated with nafamostat mesilate, a synthetic protease inhibitor.METHODS:
A total of 247 patients who underwent an ERCP were evaluated prospectively. Potential risk factors of post-ERCP pancreatitis in patients pretreated with nafamostat mesilate were evaluated.RESULTS:
Twenty-four patients (9.7%) and nine patients (3.6%) developed post-ERCP hyperamylasemia and pancreatitis, respectively. As determined by univariate analysis among the potential risk factors, we found a procedure time over 20 minutes, pancreatic duct cannulation over four times, prior post-ERCP pancreatitis and the absence of a common bile duct (CBD) stone as risk factors for post-ERCP hyperamylasemia. We also found a patient age under 60 years, a procedure time over 20 minutes, pancreatic duct cannulation over four times and the absence of a CBD stone as risk factors for post-ERCP pancreatitis (p<0.05). As determined by multivariate analysis, pancreatic cannulation over four times is independently associated with post-ERCP hyperamylasemia (p=0.038; OR, 5.165; 95% CI, 1.093~24.412) and post-ERCP pancreatitis (p=0.002; OR, 33.122; 95% CI, 3.526~311.138).CONCLUSIONS:
A repeated pancreatic duct cannulation is the most important risk factor for post-ERCP pancreatitis in patients pretreated with nafamostat mesilate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatic Ducts
/
Pancreatitis
/
Protease Inhibitors
/
Catheterization
/
Multivariate Analysis
/
Prospective Studies
/
Risk Factors
/
Cholangiopancreatography, Endoscopic Retrograde
/
Common Bile Duct
/
Mesylates
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Gastrointestinal Endoscopy
Year:
2008
Type:
Article
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