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Naringenin stimulates cholecystokinin secretion in STC-1 cells
Nutrition Research and Practice ; : 146-150, 2014.
Article in English | WPRIM | ID: wpr-183209
ABSTRACT
BACKGROUND/

OBJECTIVES:

Cholecystokinin (CCK), a hormone or neuropeptide, is secreted in response to intraluminal nutrients by enteroendocrine I-cells of the intestine and has important physiological actions related to appetite regulation and satiety. The stimulation on CCK secretion from the intestine is of potential relevance for body weight management. Naringenin (4',5,7-trihydroxyflavanone) and its glycoside naringin (naringenin 7-rhamnoglucoside) have been reported to have many biological functions. In the current study, we investigated the question of whether naringenin and naringin could stimulate CCK secretion and then examined the mechanisms involved in CCK release. MATERIALS/

METHODS:

STC-1 cells were used as a model of enteroendocrine cells. CCK release and changes in intracellular Ca2+ ([Ca2+]i) were measured after incubation of cells with naringenin and naringin for 1 h.

RESULTS:

Naringenin caused significant (P < 0.05) stimulation of CCK secretion, but naringin did not. In addition, regarding the secretory mechanisms, naringenin-induced CCK secretion involved increases in [Ca2+]i, influx of extracellular Ca2+, at least in part, and activation of TRP channels, including TRPA1.

CONCLUSION:

Findings of this study suggest that naringenin could have a role in appetite regulation and satiety.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Appetite / Appetite Regulation / Body Weight / Neuropeptides / Cholecystokinin / Enteroendocrine Cells / Intestines Type of study: Prognostic study Language: English Journal: Nutrition Research and Practice Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Appetite / Appetite Regulation / Body Weight / Neuropeptides / Cholecystokinin / Enteroendocrine Cells / Intestines Type of study: Prognostic study Language: English Journal: Nutrition Research and Practice Year: 2014 Type: Article