Cognitive Function in Non-Insulin Dependent Diabetic Patients : P300 Event-related Potentials and Neuropsychological Tests
Journal of the Korean Neurological Association
;
: 803-815, 1997.
Article
in Korean
| WPRIM
| ID: wpr-183322
ABSTRACT
BACKGROUND AND OBJECTIVE:
Several recent studies have demonstrated that cognitive function is impaired in non-insulin dependent diabetes mellitus (NIDDM) patients compared with age-matched non-diabetic controls. However, the underlying pathophysiological mechanism of this diabetic central nervous involvement remains obscure. The present study was designed to explore further whether cognitive deficits are present in NIIDDM patients who do not show apparent symptoms and signs of central nervous system damage and to evaluate the influence of clinical parameters and diabetic complications on cognitive function.METHODS:
Thirty patients over 50 years of age with NIDDM and 30 age-, sex- and education-matched normal controls were recruited for the study. P300 event-related potential test and neuropsychological tests (Mini-Mental State Examination, MMSE; Benton Visual Retention test; Digit Span Forward and Backward) were perfomed. P300 latencies were recorded according to the conventional technique using Counterpointer MK2.RESULTS:
Compared with controls, NIDDM patients showed significant impairment in MMSE (P<0.05), Benton Visual Retention (P<0.05), and Digit Span Backward (PCONCLUSIONS:
This study suggest that 1) cognitive function is decreased in NIDDM patients who do not show apparent symptoms and signs of central nervous system damage, 2) P300 latency may reveal cognitive changes not detected by nouropsychological tests, and 3) P300 event-related potentials, MMSE, Benton Visual Retention and Digit Span Backward tests may be included in a battery of cognitive function tests in NIDDM patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
Triglycerides
/
Blood Glucose
/
Central Nervous System
/
Fasting
/
Peripheral Nervous System Diseases
/
Event-Related Potentials, P300
/
Diabetes Complications
/
Diabetes Mellitus
/
Diabetes Mellitus, Type 2
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
1997
Type:
Article
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