Completion of Chronic Hepatitis C Virus Treatment in Interferon-Induced Major Depressive Disorder with Psychotic Features
Psychiatry Investigation
;
: 381-383, 2011.
Article
in English
| WPRIM
| ID: wpr-183453
ABSTRACT
Interferon (IFN)-associated psychiatric disorders can be managed without interruption to hepatitis C virus (HCV) treatment. The limited number of cases in the literature reporting psychotic depression as an adverse drug reaction to IFN resulted in discontinuation of HCV therapy. The author reports a case of a 49 year-old man with chronic HCV genotype 1a treated with pegylated interferon-alpha and ribavirin developing major depressive disorder with psychotic features. The patient was successfully treated with both an antidepressant and antipsychotic for this suspected IFN-associated adverse drug effect while continuing 12 months of uninterrupted HCV treatment and subsequently achieving sustained hepatitis C virological response. Although IFN can cause distressing psychiatric disturbances, appropriate treatment with psychotropic agents and careful monitoring allows patients to be maintained on a full course of HCV treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychotic Disorders
/
Ribavirin
/
Interferons
/
Interferon-alpha
/
Hepatitis C
/
Hepacivirus
/
Hepatitis C, Chronic
/
Depression
/
Depressive Disorder, Major
/
Drug-Related Side Effects and Adverse Reactions
Limits:
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2011
Type:
Article
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