Response of fetal rat calvarial cells on mineral trioxide aggregate after IL-1beta stimulation / 대한치주과학회지
The Journal of the Korean Academy of Periodontology
;
: 359-365, 2009.
Article
in Korean
| WPRIM
| ID: wpr-183841
ABSTRACT
PURPOSE:
The purpose of this study was to investigate the ability of Mineral trioxide aggregate(MTA) to support osteoclastic differentiation from fetal rat calvarial cell.METHODS:
In this study, response of IL-6, RANKL, and OPG in fetal rat calvarial cells stimulated with IL-1beta on MTA was evaluated by ELISA and RT-PCR.RESULTS:
The results were as follows; there was no significant difference between glass and MTA at 5days. In ELISA analysis, Glass group and MTA group showed similar IL-6 expression, Glass+IL-1beta group and MTA+IL-1beta group showed similar IL-6 expression. In RT-PCR analysis, Glass group and MTA group showed similar IL-6, RANKL, OPG mRNA expression, MTA+IL-1beta group and Glass+IL-1beta group showed 3 fold increase of IL-6 and RNAKL mRNA expression when compared with MTA group. All groups showed similar OPG mRNA expression.CONCLUSIONS:
MTA does not suppress cell proliferation and increase the proinflammatory cytokine that induce osteoclastogenesis. Thus, MTA is biocompatible material that could be used in various clinical conditions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoclasts
/
Oxides
/
Biocompatible Materials
/
RNA, Messenger
/
Enzyme-Linked Immunosorbent Assay
/
Cytokines
/
Interleukin-6
/
Silicates
/
Calcium Compounds
/
Aluminum Compounds
Limits:
Animals
Language:
Korean
Journal:
The Journal of the Korean Academy of Periodontology
Year:
2009
Type:
Article
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