Correlation between Metabolic Syndrome and Cognition in the Elderly / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 349-356, 2006.
Article
in Korean
| WPRIM
| ID: wpr-183932
ABSTRACT
OBJECTIVE:
The purpose of this study is to find out the effect of ApoE genotype in correlation between metabolic syndrome and cognition of the elderly in the community.METHODS:
A total of 1,305 subjects (440 men and 865 women) aged 60-98 years were analyzed from preliminary data of Gwangju Dementia and MCI Study (GDEMCIS). The metabolic syndrome was assessed as defined by the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, family history of dementia and stroke, and Korean version-Mini Mental State Examination (K-MMSE). We also examined ApoE genotype and analyzed associated factors with metabolic syndrome.RESULTS:
These Metabolic syndrome was present in 28.6% of the subjects (13.4% of men and 36.3% of women). On multiple logistic regression analysis, low serum HDL cholesterol was associated with an increased risk for cognitive impairment (K-MMSE score < or = 17) adjusted by age, sex, educational level, and smoking in the presence of ApoE epsilon4 allele (OR 0.95, 95% CI 0.92-0.99).CONCLUSION:
These results suggest that serum HDL cholesterol may affect cognitive function in the elderly in the presence of ApoE epsilon4 allele.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins E
/
Smoke
/
Smoking
/
Logistic Models
/
Adenosine Triphosphate
/
Cholesterol
/
Surveys and Questionnaires
/
Cognition
/
Stroke
/
Dementia
Type of study:
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2006
Type:
Article
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