Decreased CD5+ B cells during the acute phase of Kawasaki disease
Yonsei Medical Journal
;
: 52-58, 1996.
Article
in English
| WPRIM
| ID: wpr-183983
ABSTRACT
We investigated the changes of CD5+ B cells in the peripheral blood of 20 Kawasaki disease (KD) patients. The percentage of CD5+ B cells in the total lymphocytes and in the total B cells significantly decreased during the acute phase of KD(p< 0.01), compared to that in the age-matched normal control subjects. After intravenous immunoglobulin(IVIG) treatment, the percentage of CD5+ B cells increased, but was still lower than that in the normal controls(p< 0.01). During the convalescent phase of the disease, the percentage of CD5+ B cells was restored to the normal levels. The levels of CD5+ B cell percentage in the total B cells of the patients with acute febrile disease showed similar levels to age-matched normal controls. The decreased CD5+ B cells in the patients with KD provides an additional abnormal immunological finding during the acute phase of the disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
B-Lymphocytes
/
Acute Disease
/
CD5 Antigens
/
Mucocutaneous Lymph Node Syndrome
Limits:
Child
/
Female
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
1996
Type:
Article
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