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The Prognostic Value of Residual Volume/Total Lung Capacity in Patients with Chronic Obstructive Pulmonary Disease
Journal of Korean Medical Science ; : 1459-1465, 2015.
Article in English | WPRIM | ID: wpr-184036
ABSTRACT
The prognostic role of resting pulmonary hyperinflation as measured by residual volume (RV)/total lung capacity (TLC) in chronic obstructive pulmonary disease (COPD) remains poorly understood. Therefore, this study aimed to identify the factors related to resting pulmonary hyperinflation in COPD and to determine whether resting pulmonary hyperinflation is a prognostic factor in COPD. In total, 353 patients with COPD in the Korean Obstructive Lung Disease cohort recruited from 16 hospitals were enrolled. Resting pulmonary hyperinflation was defined as RV/TLC > or = 40%. Multivariate logistic regression analysis demonstrated that older age (P = 0.001), lower forced expiratory volume in 1 second (FEV1) (P < 0.001), higher St. George Respiratory Questionnaire (SGRQ) score (P = 0.019), and higher emphysema index (P = 0.010) were associated independently with resting hyperinflation. Multivariate Cox regression model that included age, gender, dyspnea scale, SGRQ, RV/TLC, and 6-min walking distance revealed that an older age (HR = 1.07, P = 0.027), a higher RV/TLC (HR = 1.04, P = 0.025), and a shorter 6-min walking distance (HR = 0.99, P < 0.001) were independent predictors of all-cause mortality. Our data showed that older age, higher emphysema index, higher SGRQ score, and lower FEV1 were associated independently with resting pulmonary hyperinflation in COPD. RV/TLC is an independent risk factor for all-cause mortality in COPD.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Pulmonary Emphysema / Respiratory Function Tests / Residual Volume / Total Lung Capacity / Vital Capacity / Forced Expiratory Flow Rates / Forced Expiratory Volume / Surveys and Questionnaires / Walking Type of study: Prognostic study Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Pulmonary Emphysema / Respiratory Function Tests / Residual Volume / Total Lung Capacity / Vital Capacity / Forced Expiratory Flow Rates / Forced Expiratory Volume / Surveys and Questionnaires / Walking Type of study: Prognostic study Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2015 Type: Article