Application of aptamers for assessment of vaccine efficacy
Clinical and Experimental Vaccine Research
;
: 160-163, 2017.
Article
in English
| WPRIM
| ID: wpr-184068
ABSTRACT
Assessing antigen concentration of vaccine is essential step in determining the quality of the vaccine prior to vaccination. After vaccination, vaccine-induced antibody titer should also be measured to verify the vaccine efficacy. Since conventional assay used for vaccine concentrations and induced Ab-titers is antibody-based enzyme-linked immunosorbent assay, the assay inevitably brings drawbacks of antibody such as high cost for production, limited stability, and inconsistent quality between lot-to-lots. Aptamer is single-stranded nucleic acid having three-dimensional structure and has features overcoming limitations of antibody. This review will briefly introduce the features of aptamer and potential of aptamer-based system for evaluation of vaccine efficacy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Enzyme-Linked Immunosorbent Assay
/
Vaccines
/
Vaccination
/
Antibodies
Language:
English
Journal:
Clinical and Experimental Vaccine Research
Year:
2017
Type:
Article
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