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Epigenetic Mechanisms of Early Adverse Experience in the Development of Depression / 대한정신약물학회지
Korean Journal of Psychopharmacology ; : 91-100, 2014.
Article in Korean | WPRIM | ID: wpr-18407
ABSTRACT
Depression is a common mental illness with a high lifetime prevalence rate in the general population. However, the pathophysiology of depression is still poorly understood. Recent studies showed that environmental factors can affect gene expression by modifying epigenetic factors. Early life stress (ELS) is likely a risk factor of lifetime vulnerability to stress and development of depression. ELS or stressful lifetime can induce changes in gene expression through epigenetic mechanism, such as DNA methylation or histone modification. In this article, recent researches on the epigenetic mechanisms of depression will be discussed.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stress, Psychological / Histones / Gene Expression / Prevalence / Risk Factors / DNA Methylation / Depression / Epigenomics Type of study: Etiology study / Prevalence study / Risk factors Language: Korean Journal: Korean Journal of Psychopharmacology Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Stress, Psychological / Histones / Gene Expression / Prevalence / Risk Factors / DNA Methylation / Depression / Epigenomics Type of study: Etiology study / Prevalence study / Risk factors Language: Korean Journal: Korean Journal of Psychopharmacology Year: 2014 Type: Article