Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases
Journal of Pathology and Translational Medicine
;
: 422-427, 2017.
Article
in English
| WPRIM
| ID: wpr-184095
ABSTRACT
Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to atypical MGA, ductal carcinoma in situ or invasive carcinoma. Immunohistochemically, all cases were triple-negative and expression of S-100 protein gradually decreased as the lesions progressed from MGA to atypical MGA and carcinoma. Three cases showed acinic cell differentiation with reactivity to α1-antitrypsin, and one case was metaplastic carcinoma. During clinical follow-up, one patient developed local recurrence. Carcinoma arising in MGA is a rare but distinct subset of triple-negative breast cancer with characteristic histologic and immunohistochemical findings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Breast
/
S100 Proteins
/
Follow-Up Studies
/
Carcinoma, Intraductal, Noninfiltrating
/
Acinar Cells
/
Fibrocystic Breast Disease
/
Triple Negative Breast Neoplasms
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Pathology and Translational Medicine
Year:
2017
Type:
Article
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