Effect of Low-Dose Triple Therapy Using Gabapentin, Amitriptyline, and a Nonsteroidal Anti-Inflammatory Drug for Overactive Bladder Symptoms in Patients With Bladder Pain Syndrome / 대한배뇨장애요실금학회지
International Neurourology Journal
;
: 78-82, 2013.
Article
in English
| WPRIM
| ID: wpr-184782
ABSTRACT
PURPOSE:
Patients with bladder pain syndrome/interstitial cystitis (BPS/IC) can have pain as a main symptom and overactive bladder (OAB) symptoms that are directly or indirectly related to a major mechanism that causes pain. The primary purpose of this study is firstly to identify the prevalence rate of OAB symptoms in patients with BPS/IC, secondly to identify changes in OAB symptoms after low-dose triple therapy, and thirdly to build a theoretical foundation to improve quality of life for patients.METHODS:
Patients who met the inclusion criteria of BPS/IC through basic tests including the O'Leary-Sant symptom index, overactive bladder symptom score (OABSS), and visual analog scale (VAS) were identified. Treatment-based changes in OAB symptoms were identified using the IC Symptom Index and IC Problem Index (ICSI/ICPI), OABSS, and VAS before, and 4 and 12 weeks after low-dose triple therapy.RESULTS:
The patients consisted of 3 men and 20 women, and their mean age was 61.9 years (41.0-83.2 years). Comparing values before treatment, and 4 and 12 weeks after treatment (baseline vs. 4 weeks to baseline vs. 12 weeks), the rates of improvement were as follows ICSI, 44.2% to 63.7%; ICPI, 46.9% to 59.4%; OABSS, 34.3% to 58.2%; and VAS, 53.6% to 75.0%, which showed statistically significant differences (P0.05).CONCLUSIONS:
Low-dose triple therapy in BPS/IC results in a clear decrease in OAB symptoms in the first 4 weeks after treatment, and additional treatment for 8 weeks had a partial effect with varied statistical significances depending on the questionnaires.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Urinary Bladder
/
Prevalence
/
Cystitis, Interstitial
/
Sperm Injections, Intracytoplasmic
/
Cyclohexanecarboxylic Acids
/
Cystitis
/
Urinary Bladder, Overactive
/
Gamma-Aminobutyric Acid
/
Amines
Type of study:
Diagnostic study
/
Prevalence study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
International Neurourology Journal
Year:
2013
Type:
Article
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