Effect of Short-Term Hypothyroid State on Lipid Profile and Cardiovascular Risk Markers in Subjects Preparing Radioactive Iodine Therapy / 대한갑상선학회지
Journal of Korean Thyroid Association
;
: 172-179, 2014.
Article
in Korean
| WPRIM
| ID: wpr-184789
ABSTRACT
BACKGROUND AND OBJECTIVES:
The relationship between short-term hypothyroidism due to levothyroxine (LT4) withdrawal for radioactive iodine (RI) therapy in patients with differentiated thyroid cancer (DTC) and risk of cardiovascular disease is not clear. In this study, we evaluated the impact of short-term overt hypothyroidism on lipid profiles and cardiovascular parameters in patients with DTC. MATERIALS ANDMETHODS:
We recruited 195 patients with DTC who were preparing RI therapy from March 2008 to February 2012. We analyzed the effect of thyroid stimulating hormone (TSH) level on the clinical, biochemical, and cardiovascular risk markers at the end of LT4 withdrawal protocol (P2).RESULTS:
After LT4 withdrawal (P2), TSH and total cholesterol (TC) levels were significantly increased (p121 microIU/mL), all values did not have a statistical significant meaning except Apo A1.CONCLUSION:
Short-term hypothyroidism induced worsening of lipid metabolic parameters, but not enough to induce the cardiovascular risk in patients with thyroid cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins
/
Apolipoproteins B
/
Aspartate Aminotransferases
/
Reference Values
/
Thyroxine
/
Triglycerides
/
Uric Acid
/
Bilirubin
/
C-Reactive Protein
/
Thyroid Neoplasms
Type of study:
Etiology study
/
Practice guideline
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Thyroid Association
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS