Molecular Mechanisms of Appetite Regulation
Diabetes & Metabolism Journal
;
: 391-398, 2012.
Article
in English
| WPRIM
| ID: wpr-184817
ABSTRACT
The prevalence of obesity has been rapidly increasing worldwide over the last several decades and has become a major health problem in developed countries. The brain, especially the hypothalamus, plays a key role in the control of food intake by sensing metabolic signals from peripheral organs and modulating feeding behaviors. To accomplish these important roles, the hypothalamus communicates with other brain areas such as the brainstem and reward-related limbic pathways. The adipocyte-derived hormone leptin and pancreatic beta-cell-derived insulin inform adiposity to the hypothalamus. Gut hormones such as cholecystokinin, peptide YY, pancreatic polypeptide, glucagon-like peptide 1, and oxyntomodulin transfer satiety signals to the brain and ghrelin relays hunger signals. The endocannabinoid system and nutrients are also involved in the physiological regulation of food intake. In this article, we briefly review physiological mechanisms of appetite regulation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Appetite
/
Appetite Regulation
/
Brain
/
Brain Stem
/
Cholecystokinin
/
Pancreatic Polypeptide
/
Developed Countries
/
Prevalence
/
Hunger
/
Peptide YY
Type of study:
Prevalence study
Language:
English
Journal:
Diabetes & Metabolism Journal
Year:
2012
Type:
Article
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