Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS
Experimental Neurobiology
;
: 233-240, 2016.
Article
in English
| WPRIM
| ID: wpr-184906
ABSTRACT
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that leads to a progressive muscle wasting and paralysis. The pathological phenotypes are featured by severe motor neuron death and glial activation in the lumbar spinal cord. Proposed ALS pathogenic mechanisms include glutamate cytotoxicity, inflammatory pathway, oxidative stress, and protein aggregation. However, the exact mechanisms of ALS pathogenesis are not fully understood yet. Recently, a growing body of evidence provides a novel insight on the importance of glial cells in relation to the motor neuronal damage via the non-cell autonomous pathway. Accordingly, the aim of the current paper is to overview the role of astrocytes and microglia in the pathogenesis of ALS and to better understand the disease mechanism of ALS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paralysis
/
Phenotype
/
Spinal Cord
/
Neuroglia
/
Astrocytes
/
Microglia
/
Oxidative Stress
/
Glutamic Acid
/
Neurodegenerative Diseases
/
Amyotrophic Lateral Sclerosis
Type of study:
Etiology study
Language:
English
Journal:
Experimental Neurobiology
Year:
2016
Type:
Article
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