Frequency and Clinical Manifestations of Human Herpesvirus-6 Infection in Hematopoietic Stem Cell Transplant Recipients / 감염
Korean Journal of Infectious Diseases
;
: 280-286, 2000.
Article
in Korean
| WPRIM
| ID: wpr-185005
ABSTRACT
BACKGROUND:
Human herpesvirus-6 (HHV-6) is recently known as a major pathogen associated with various diseases in hematopoietic stem cell transplant (HSCT) recipients. We prospectively evaluated the frequency and clinical manifestations of HHV-6 infection in HSCT recipient in a single HSCT center in Korea.METHODS:
Serum and peripheral blood mononuclear cells (PBMC) were weekly obtained from 1 week before HSCT to 4 weeks after HSCT. Three months' and six months' samples were obtained in some cases. HHV-6 was detected by nested polymerase chain reaction.RESULTS:
Two hundred and seventy-eight samples from 54 HSCT recipients were collected from February to November, 1999. HHV-6 was detected in 32 out of 54 recipients (59.3%) at least once during study period in their PBMC or serum. HHV-6 DNA positive rate of PBMC and serum samples were 38.1% and 4.3 % respectively. HHV-6 DNAemia (HHV-6 DNA positive in serum) was detected and peaked at 2 weeks after HSCT and continued to 4 weeks. HHV-6 DNA in peripheral blood was not associated with unexplained fever, acute graft-versus-host disease, engraftment delay, or cytomegalovirus infection in this study.CONCLUSION:
Reactivation and development of DNAemia of HHV-6 certainly occurred after HSCT, but the clinical manifestations and association with other diseases were unclear in this study. The large-scaled, nation-wide detail studies about the prevalence and characteristics of HHV-6 in general population and patients of specific disease entities must be considered.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transplantation
/
DNA
/
Hematopoietic Stem Cells
/
Polymerase Chain Reaction
/
Prevalence
/
Prospective Studies
/
Herpesvirus 6, Human
/
Cytomegalovirus Infections
/
Hematopoietic Stem Cell Transplantation
/
Fever
Type of study:
Observational study
/
Prevalence study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Infectious Diseases
Year:
2000
Type:
Article
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