In Vitro Activities of LY303366 against Clinical Isolates of Candida spp., Cryptococcus neoformans and Aspergillus spp / 감염
Korean Journal of Infectious Diseases
;
: 274-279, 2000.
Article
in Korean
| WPRIM
| ID: wpr-185006
ABSTRACT
BACKGROUND:
Fungal infection became more prevalent with the increase of compromised patients, requiring less toxic potent antifungal agents. LY303366, a new semisynthetic antifungal agent of echinocandin class, was reported to be active against Candida spp. and filamentous fungi.METHODS:
In vitro activities of LY303366 were determined against clinical isolates of fungi by NCCLS broth microdilution test using RPMI 1640 medium.RESULTS:
MIC90s of LY303366 were 0.03 microgram/mL for C. albicans, 2 microgram/mL for C. parapsilosis, 0.12 microgram/mL for C. tropicalis. LY303366 was more active against C. albicans and C. tropicalis than amphotericin B, 5-fluorocytosine, or fluconazole. It was less active than other agents against C. neoformans. MIC range of LY303366 against Aspergillus spp. was 8->16 microgram/mL.CONCLUSION:
Very high in vitro activity of LY303366 against recent clinical isolates of Candida spp. including fluconazole resistant ones, suggests its usefulness for the treatment of candidal infections.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aspergillus
/
Candida
/
Fluconazole
/
Amphotericin B
/
Cryptococcus
/
Cryptococcus neoformans
/
Flucytosine
/
Fungi
/
Antifungal Agents
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Infectious Diseases
Year:
2000
Type:
Article
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