Clinical and Histopathological Investigation of Seborrheic Keratosis
Annals of Dermatology
;
: 152-158, 2016.
Article
in English
| WPRIM
| ID: wpr-185204
ABSTRACT
BACKGROUND:
Seborrheic keratosis (SK) is one of the most common epidermal tumors of the skin. However, only a few large-scale clinicohistopathological investigations have been conducted on SK or on the possible correlation between histopathological SK subtype and location.OBJECTIVE:
The aim of this study was to analyze the clinical and histopathological features of a relatively large number of cases of diagnosed SK.METHODS:
Two hundred and seventy-one pathology slides of skin tissue from patients with clinically diagnosed SK and 206 cases of biopsy-proven SK were analyzed. The biopsy-proven cases of SK were assessed for histopathological subclassification. The demographic, clinical, and histopathological data of the patients were collected for analysis of associated factors.RESULTS:
The most frequent histopathological subtype was the acanthotic type, followed by mixed, hyperkeratotic, melanoacanthoma, clonal, irritated, and adenoid types; an unexpectedly high percentage (9.2%) of the melanoacanthoma variant was observed. The adenoid type was more common in sun-exposed sites than in sun-protected sites (p=0.028). Premalignant and malignant entities together represented almost one-quarter (24.2%) of the clinicopathological mismatch cases (i.e., mismatch between the clinical and histopathological diagnoses). Regarding the location of SK development, the frequency of mismatch for the sun-exposed areas was significantly higher than that for sun-protected areas (p=0.043).CONCLUSION:
The adenoid type was more common in sun-exposed sites. Biopsy sampling should be performed for lesions situated in sun-exposed areas to exclude other premalignant or malignant diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Skin
/
Biopsy
/
Adenoids
/
Classification
/
Keratosis, Seborrheic
Limits:
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2016
Type:
Article
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