Dependence Potential of Tramadol: Behavioral Pharmacology in Rodents
Biomolecules & Therapeutics
;
: 558-562, 2014.
Article
in English
| WPRIM
| ID: wpr-185386
ABSTRACT
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Rodentia
/
Tramadol
/
Behavior, Animal
/
Substance-Related Disorders
/
Head
/
Korea
Limits:
Animals
Country/Region as subject:
Asia
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2014
Type:
Article
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