A Case of Agranulocytosis and Soft Tissue Abscess after Increasing Methimazole Dose in a Patient with Graves Disease under Long-term Mainternance Therapy / 대한갑상선학회지
Journal of Korean Thyroid Association
;
: 54-57, 2011.
Article
in Korean
| WPRIM
| ID: wpr-185561
ABSTRACT
Antithyroid drugs (ATD) has been widely used to treat Graves' disease. However agranulocytosis, a serious fatal complication of ATD treatment, occurs in about 0.5 percent. The symptoms may mimic viral infections (fever, sore throat), and the potentially life-threatening pyogenic infections can go unrecognized initially. The median duration of drug exposure before the onset of acute agranulocytosis is within 30 days in most cases. We report a case of agranulocytosis with secondary soft tissue infection and abscess occuring after increasing the dose of methimazole in a woman who had taken methimazole for more than 10 years. We administered broad-spectrum antibiotics and aspirated the soft tissue abscess. A review of the medical literature regarding agranulocytosis in the setting of ATDs is presented.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antithyroid Agents
/
Graves Disease
/
Soft Tissue Infections
/
Agranulocytosis
/
Abscess
/
Hydrazines
/
Methimazole
/
Anti-Bacterial Agents
Limits:
Female
/
Humans
Language:
Korean
Journal:
Journal of Korean Thyroid Association
Year:
2011
Type:
Article
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