Cancer Epigenetics / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 1-12, 2004.
Article
in Korean
| WPRIM
| ID: wpr-185702
ABSTRACT
Knowledge regarding molecular events of cancer development has been rapidly accumulated during the last decade. The discovery of tumor suppressor gene-silencing by aberrant promoter CpG island hypermethylation and histone-directed chromatin remodeling has led epigenetics to its recognition as an important alternative mechanism for carcinogenesis. Epigenetics does not involve changes in nucleotide sequences, but it affects on genetic composition in many ways. Cancer cells integratively co-opt genetic and epigenetic mechanisms to acquire different aspects of carcinogenetic phenotypes. Since epigenetic changes can be reversed with relative ease, the research of cancer epigenetics provides great potential for new therapeutic regimens.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
English Abstract
/
Cell Transformation, Neoplastic
/
Genes, Tumor Suppressor
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Promoter Regions, Genetic
/
Genomic Imprinting
/
CpG Islands
/
DNA Methylation
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Gene Silencing
/
Neoplasms
Limits:
Humans
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2004
Type:
Article
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