Clinical Usefulness of Human Immunodeficiency Virus(HIV)-1 p24 Antigen Testing / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 149-155, 1997.
Article
in Korean
| WPRIM
| ID: wpr-185764
ABSTRACT
BACKGROUND:
Recently some countries such as U.S.A. and Canada where human immunodeficiency virus(HIV) infection is rather prevalent, included HIV-1 p24 antigen test as a routine donor blood screening. This study was performed to evaluate the advantage of additional p24 antigen testing for the prevention of transfusion-associated AIDS infection in Korea.METHODS:
Blood collected from 1726 volunteer blood donors, 16 HIV-positive patients, 39 sera from 4 commercial seroconversion panels, 15 sera included in low titer performance panel were tested with HIV-1 p24 Antigen ELISA Test System(Ortho Diagnostic Systems, U.S.A.). Anti-HIV antibody was also measured in parallel employing commercial kits produced by two world-famous companies. For some sera, western blot testing was additionally done.RESULTS:
False-positive rate of p24 antigen testing was 0.06%. In 2 examples from 4 seroconversion panels, the p24 antigen test detected HIV infection 1-25 days and 11-47 days earlier than anti-HIV tests.CONCLUSION:
Additional p24 antigen testing was found to have a potential to reduce transfusion-associated HIV infections. Including the p24 antigen testing as a routine donor screening should be considered if the number of transfusion-associated HIV infections continues to grow in Korea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tissue Donors
/
Volunteers
/
Blood Donors
/
Canada
/
Enzyme-Linked Immunosorbent Assay
/
HIV Infections
/
Mass Screening
/
Blotting, Western
/
HIV-1
/
Donor Selection
Type of study:
Screening study
Limits:
Humans
Country/Region as subject:
North America
/
Asia
Language:
Korean
Journal:
Korean Journal of Blood Transfusion
Year:
1997
Type:
Article
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