Atypical necrotizing encephalitis associated with systemic canine distemper virus infection in pups
Journal of Veterinary Science
;
: 409-411, 2011.
Article
in English
| WPRIM
| ID: wpr-186138
ABSTRACT
This report describes the naturally occurring atypical neuropathological manifestation of systemic canine distemper virus (CDV) infection in two 16-day-old Pit Bull pups. CDV-induced changes affected the gray and white matter of the forebrain while sparing the hindbrain. Histologically, there was necrosis with destruction of the nervous parenchyma due to an influx of inflammatory and reactive cells associated with eosinophilic intranuclear inclusion bodies within glial cells. Positive immunoreactivity against CDV antigens was predominantly observed within astrocytes and neurons. RT-PCR was used to amplify CDV-specific amplicons from brain fragments. These findings suggest the participation of CDV in the etiopathogenesis of these lesions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Central Nervous System
/
Distemper
/
Distemper Virus, Canine
/
Encephalitis
/
Necrosis
/
Antigens, Viral
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2011
Type:
Article
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