Relevance of Exhaled Nitric Oxide Levels to Asthma Control Test Scores and Spirometry Values in Children with Atopic Asthma / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 24-31, 2011.
Article
in Korean
| WPRIM
| ID: wpr-186392
ABSTRACT
PURPOSE:
Fractional exhaled nitric oxide (FeNO) has been proposed as a tool for assessing airway inflammation in patients with atopic asthma. We evaluated the relationship between FeNO with asthma control test (ACT) scores and spirometry values in children with atopic asthma.METHODS:
One hundred twenty-six children with atopic asthma, 8-16 years of age, were included in the study. None of the participants received regular controller therapy for at least 4 weeks before the study. The ACT (for children >12 years of age) or the Childhood Asthma Control Test (C-ACT; for children between the ages of 8 and 11 years of age), FeNO measurements and pulmonary function tests were performed.RESULTS:
The geometric mean of the FeNO in children with atopic asthma (16.1 parts per billion [ppb]; 95% CI, 14.5-17.8 ppb) was significantly higher than that healthy controls (7.5 ppb; 95% CI, 7.0-8.1 ppb; P 20 in 82% of enrolled patients and correlated with the %FEV1, FEV1/FVC, and %FEF25-75. However, FeNO was not related to %FEV1, FEV1/FVC, %FEF25-75, and scores for asthma controls. FeNO levels in asthmatic children were not significantly different with respect to age, gender, BMI, and tobacco exposure.CONCLUSION:
FeNO was not related to the spirometry values and scores for asthma control. Measurement of FeNO may be a complementary tool in the assessment of asthma control.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respiratory Function Tests
/
Asthma
/
Spirometry
/
Nicotiana
/
Inflammation
/
Nitric Oxide
Limits:
Child
/
Humans
Language:
Korean
Journal:
Pediatric Allergy and Respiratory Disease
Year:
2011
Type:
Article
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