Effects of Subthalamic Nucleus Deep Brain Stimulation on the Phonation and Articulation of the Patients with Parkinson's Disease
Journal of the Korean Neurological Association
;
: 472-477, 2004.
Article
in Korean
| WPRIM
| ID: wpr-186490
ABSTRACT
BACKGROUND:
The purpose of this study was to investigate the effects of the subthalamic nucleus (STN) deep brain stimulation (DBS) on the phonation and articulation of patients with Parkinson's disease (PD).METHODS:
Seven PD patients who underwent bilateral STN DBS were included. The patients were asked to make and sustain the vowel sounds /a/ and /i/ as long as possible and to repeat nonsense syllables, /pa/, /ta/, /ka/ and /pataka/ as quickly as possible for 3 seconds. When the patients were administered levodopa `on' and `off' treatments, we evaluated the effect of DBS on the maximum phonation time (MPT), jitter (pitch perturbation), shimmer (intensity perturbation), tremor index and diadochokinetic rate (DDK). In each condition, using a Unified Parkinson's Disease Rating Scale score, we also measured the motor disability of the patients.RESULTS:
During levodopa `off', both the DBS and levodopa treatment caused significant prolongation of the MPT of the vowels /a/ and /i/. Acoustic analysis showed that DBS had an effect on shimmer only when the patients were levodopa `off'. At the articulatory level, no significant changes were found in the diadochokinetic rate under any conditions. However, there was a correlation between the amount of improvement of voice tremor and sum of UPDRS scores measuring `tremor at rest' and `postural tremor'.CONCLUSIONS:
In patients with advanced PD, STN DBS improves phonation, but had limited effects on articulation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Phonation
/
Tremor
/
Voice
/
Acoustics
/
Levodopa
/
Subthalamic Nucleus
/
Deep Brain Stimulation
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
2004
Type:
Article
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