A Case of Ulcerative Colitis with Prolonged Remission Following Azathioprine-Induced Pancytopenia
Intestinal Research
;
: 85-89, 2008.
Article
in Korean
| WPRIM
| ID: wpr-186562
ABSTRACT
Azathioprine (AZA) is widely used for the treatment of inflammatory bowel disease. Bone marrow suppression is a common side effect with AZA treatment. However, data from AZA trials has indicated that a leukocyte count less than 5,000/mm3 was a good predictor of induction and maintenance of remission. Moreover, there is evidence that eradication of sensitized leukocytes by leukapheresis or bone marrow transplantation improves inflammatory bowel disease. We report a case of a patient who had a chronic relapse of ulcerative colitis requiring the frequent use of systemic steroids, but presented prolonged remission following AZA-induced severe pancytopenia. Also colonoscopy showed accelerated healing of diffuse active ulcers following just recovery from pancytopenia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancytopenia
/
Recurrence
/
Steroids
/
Azathioprine
/
Ulcer
/
Bone Marrow
/
Inflammatory Bowel Diseases
/
Colitis, Ulcerative
/
Colonoscopy
/
Bone Marrow Transplantation
Limits:
Humans
Language:
Korean
Journal:
Intestinal Research
Year:
2008
Type:
Article
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