Regulation of Muscle Microcirculation in Health and Diabetes
Diabetes & Metabolism Journal
;
: 83-89, 2012.
Article
in English
| WPRIM
| ID: wpr-186638
ABSTRACT
Insulin increases microvascular perfusion and substrate exchange surface area in muscle, which is pivotal for hormone action and substrate exchange, by activating insulin signaling cascade in the endothelial cells to produce nitric oxide. This action of insulin is closely coupled with its metabolic action and type 2 diabetes is associated with both metabolic and microvascular insulin resistance. Muscle microvascular perfusion/volume can be assessed by 1-methylxanthine metabolism, contrast-enhanced ultrasound and positron emission tomography. In addition to insulin, several factors have been shown to recruit muscle microvasculature, including exercise or muscle contraction, mixed meals, glucagon-like peptide 1 and angiotensin II type 1 receptor (AT1R) blocker. On the other hand, factors that cause metabolic insulin resistance, such as inflammatory cytokines, free fatty acids, and selective activation of the AT1R, are capable of causing microvascular insulin resistance. Therapies targeting microvascular insulin resistance may help prevent or control diabetes and decrease the associated cardiovascular morbidity and mortality.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Perfusion
/
Vasoconstriction
/
Vasodilation
/
Xanthines
/
Insulin Resistance
/
Cytokines
/
Endothelial Cells
/
Receptor, Angiotensin, Type 1
/
Positron-Emission Tomography
/
Endothelium
Language:
English
Journal:
Diabetes & Metabolism Journal
Year:
2012
Type:
Article
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