Effects of Intraduodenal Infusions of L-phenylalanine and L-glutamine on Antropyloroduodenal Motility and Plasma Cholecystokinin in Healthy Men
Journal of Neurogastroenterology and Motility
;
: 404-413, 2015.
Article
in English
| WPRIM
| ID: wpr-186681
ABSTRACT
BACKGROUND/AIMS:
Dietary proteins have potent eating-inhibitory and glucose-lowering effects, which may be mediated via effects of amino acids on gastrointestinal hormone and motor function, although little information is available. We have now evaluated the effects of L-phenylalanine (L-Phe) and L-glutamine (L-Gln) on antropyloroduodenal motility and plasma cholecystokinin (CCK) concentrations.METHODS:
Two double-blind, 3-way cross-over studies were performed, each including 10 healthy, normal-weight men. We determined the antropyloroduodenal motor and plasma CCK responses to 90-minute intraduodenal infusions of L-Phe (study A) or L-Gln (study B), each at 0.15 kcal/min (total 13.5 kcal), or 0.45 kcal/min (total 40.5 kcal), or saline (control), in randomized fashion.RESULTS:
Intraduodenal L-Phe at 0.45 kcal/min, but not at 0.15 kcal/min, suppressed antral (P < 0.01), and stimulated phasic (P < 0.01), but not tonic, pyloric, or duodenal pressures, while L-Phe at both 0.15 kcal/min and 0.45 kcal/min stimulated plasma CCK. In contrast, L-Gln had no effect on antral, duodenal or pyloric pressures, or plasma CCK.CONCLUSIONS:
Intraduodenal infusions of L-Phe and L-Gln, in doses of 0.15 kcal/min and 0.45 kcal/min for 90 minutes, have different effects on antropyloroduodenal motility and CCK in normal-weight men. The modulation of antral and pyloric pressures and CCK may contribute to the eating-inhibitory effects of oral L-Phe, possibly through the slowing of gastric emptying.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenylalanine
/
Plasma
/
Cholecystokinin
/
Dietary Proteins
/
Cross-Over Studies
/
Eating
/
Gastric Emptying
/
Gastrointestinal Hormones
/
Gastrointestinal Motility
/
Amino Acids
Type of study:
Controlled clinical trial
Limits:
Humans
/
Male
Language:
English
Journal:
Journal of Neurogastroenterology and Motility
Year:
2015
Type:
Article
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