Inhibitory effects of biochanin A on mouse lung tumor induced by benzo(a)pyrene
Journal of Korean Medical Science
;
: 325-328, 1991.
Article
in English
| WPRIM
| ID: wpr-186738
ABSTRACT
Biochanin A, an isoflavone compound, is reported to have an inhibitory effect on benzo(a)pyrene [B(a)P] metabolism. We examined the modifying effect of biochanin A on in vivo carcinogenesis using a mouse lung tumor model. As carcinogens, a single subcutaneous injection of 0.5mg of B(a)P was given within 24 hours after birth. The test groups were injected with 0.125mg of biochanin A in 0.1ml DMSO by i.p. 3 times a week for 6 weeks after weaning. All mice were sacrificed at week 9 and the incidence and multiplicity of lung tumors were examined. Concomitant administration of biochanin A showed a significant inhibitory effect on the incidence of tumor-bearing mice (12.5%, P<0.01), as well as the mean number of tumors (0.13, P<0.001), compared with the group treated with B(a)P alone in which the incidence was 57.1% and the mean number was 1.0. These results suggest that biochanin A has inhibitory potential on the development of mouse lung tumor induced by B(a)P.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Benzo(a)pyrene
/
Body Weight
/
Survival Analysis
/
Incidence
/
Anticarcinogenic Agents
/
Genistein
/
Isoflavones
/
Lung Neoplasms
/
Animals, Newborn
/
Neoplasms, Multiple Primary
Type of study:
Incidence study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Journal of Korean Medical Science
Year:
1991
Type:
Article
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