Induction of Radiation Adaptive Response in Lymphocytes of patients Undergoing Bone Scintigraphy / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 172-177, 1999.
Article
in Korean
| WPRIM
| ID: wpr-186939
ABSTRACT
PURPOSE:
The purpose of this study was to ascertain whether radiation adaptive response could be induced by Tc-99m-methylene diphosphonate (Tc-99m-MDP) in peripheral lymphocytes of patients undergoing bone scintigraphy. MATERIALS ANDMETHODS:
Lymphocytes from 22 patients (6 males, 16 females, mean age 50+/-14 years) were collected before and after bone scintigraphy using 740 MBq Tc-99m-MDP. Lymphocytes from 10 controls (6 males, 4 females, mean age 43+/-7 years) were also collected. They were exposed challenge dose of 2 Gy gamma rays using a cell irradiator Number of ring-form and dicentric chromosomal per 600 cells (chromosomal aberrations) was counted under the light microscope.RESULTS:
Chromosomal aberrations in patients before bone scintigraphy (385.1+/-30.5) was not different from that of controls (367.8+/-36.6). However, chromosomal aberrations in patients after bone scintigraphy was significantly decreased 192.6+/-22.1 (p=0.0001).CONCLUSION:
Low dose gamma-irradiation by Tc-99m-MDP used for bone scintigraphy induces a cytogenetic adaptive response in peripheral lymphocytes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Lymphocytes
/
Radionuclide Imaging
/
Technetium Tc 99m Medronate
/
Chromosome Aberrations
/
Cytogenetics
/
Gamma Rays
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Nuclear Medicine
Year:
1999
Type:
Article
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