p22phox C242T gene polymorphism and overt diabetic nephropathy: a meta-analysis of 1,452 participants
The Korean Journal of Internal Medicine
;
: 1045-1052, 2017.
Article
in English
| WPRIM
| ID: wpr-187142
ABSTRACT
BACKGROUND/AIMS:
The p22phox C242T gene polymorphism (rs4673) may be linked to an increased susceptibility for overt diabetic nephropathy (ODN), but the study results are still inconclusive.METHODS:
To explore the relationship between p22phox C242T gene polymorphism and ODN, the current meta-analysis of 707 ODN patients and 745 controls from five individual studies was conducted. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) were evaluated by either a random or fixed effect model.RESULTS:
In our meta-analysis, a significant relationship between the p22phox C242T gene polymorphism and ODN was found under allelic (OR, 2.760; 95% CI, 1.400 to 5.450; p = 0.004), recessive (OR, 5.080; 95% CI, 1.020 to 25.430; p = 0.05), dominant (OR, 1.700; 95% CI, 1.167 to 2.477; p = 0.006), homozygous (OR, 3.900; 95% CI, 1.022 to 14.889; p = 0.046), heterozygous (OR, 1.523; 95% CI, 1.167 to 1.986; p = 0.002), and additive genetic models (OR, 2.019; 95% CI, 1.232 to 3.309; p = 0.005).CONCLUSIONS:
A positive correlation between p22phox C242T gene polymorphism and ODN risk was found. The T allele carriers of p22phox C242T gene polymorphism might be predisposed to ODN.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Odds Ratio
/
Diabetic Nephropathies
/
Alleles
/
Models, Genetic
Type of study:
Etiology study
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2017
Type:
Article
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