A Case of Congenital Central Hypoventilation Syndrome with PHOX2B Gene Mutation in a Korean Neonate
Journal of Korean Medical Science
;
: 1237-1240, 2010.
Article
in English
| WPRIM
| ID: wpr-187238
ABSTRACT
Congenital central hypoventilation syndrome (CCHS) is a life-threatening disorder with apnea and cyanosis during sleep requiring immediate endotracheal intubation during the first day of life. The PHOX2B gene has been identified as the major gene involved in CCHS. This is the first report of a Korean neonate with CCHS confirmed to have a PHOX2B mutation with expanded alleles containing 20 polyalanine repeats that is a relatively small number compared to previous cases. The patient required intermittent ventilator support during sleep only and did not suffer from any other disorders of the autonomic nerve system. He consistently needs ventilator support during sleep and remains alive. Analysis of PHOX2B gene is useful for diagnosis and appropriate therapeutic intervention of CCHS patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides
/
Transcription Factors
/
Ventilators, Mechanical
/
Sequence Analysis, DNA
/
Homeodomain Proteins
/
Asian People
/
Alleles
/
Republic of Korea
/
Genotype
/
Hypoventilation
Type of study:
Prognostic study
Limits:
Humans
/
Male
/
Infant, Newborn
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2010
Type:
Article
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